Have you heard of nootropics? This is one of the most unique subjects in my What the Heck Is series. Nootropics (Greek translation: ‘towards the mind’) is an umbrella term for, simply, any natural or synthetic compound that directly or indirectly influence cognitive brain function (1). Let’s explore more about what the heck is nootropics.

Towards the Mind

Belgian pharmacologist C.E. Giurgea and his colleagues discovered the first nootropic supplement in 1963. They describe it as a cognitive boosting substance with extremely low toxicity that can be taken for long-term use.

Today, nootropics are the categorization of cognitive enhancing supplements or foods that are used to improve concentration and boost memory power. Some areas of cognitive function include: memory, focus and attention, improved mood and energy levels.

People use nootropics for a variety of reasons including productivity and motivational effects, a boost in social ability, used as a pre-workout regime, supporting brain health in general, and to improve mental well-being.

Nootropic Supplements

Piracetam, the most popular of the nootropic, was discovered in the 1960’s by Corneliu E. Giurgea and his colleagues. Piracetam claims to improve memory, focus, enhances learning, increases alertness, as well as have neuroprotective effects.  How far fetch this may seem there is some clinical evidence to back it up.  However, more clinical trials are necessary to establish the dose response relationship and negative side effects.

  • In a meta-analysis that was published 2014, two randomized controlled trials explored the effects of piracetams on cognitive performance in patients undergoing coronary bypass surgery (184 patients average age 62.5 years) (1).

The patients agreed to consume either 12g/ 60mL IV piracetams over 30 minutes or placebo prior to surgery. Cognition was measured using the Syndrom-Kurz test. Results showed that, following treatment, immediate pictured recall, delayed pictured object recall, delayed picture recognition, immediate word recalls and letter interference (i.e., Syndrom-Kurz’s 5 subtests) were significantly better in the piracetam groups, when comparing their baseline test scores, compared to placebo.

  • In a systematic review and meta-analysis that was published in 2016, seven studies, which looked at piracetams effect on language performance, were included, with 261 overall post-stroke patients (age range: 51 to 66 years of age). In these studies, the participants agreed to consume either piracetam (4800mg) or placebo per day varying in length (i.e., 6 weeks to 6 months). Results showed that piracetam only benefited written language ability post-stroke (2).

Nootropic Foods

Foods that supposedly contain natural nootropics include: nuts, coffee, dark chocolate, berries, fish, spinach, foods that are high in choline (e.g., eggs, chicken, milk, liver), and foods that are high in glutamate (e.g., cheese, soy sauce, walnuts, peas, mushrooms). Let’s investigate berries and walnuts.

Berries are a rich source of anthocyanins and other flavonoids that may boost memory function. The following study published in 2017 investigated berries and its effect on cognitive function (3). Forty healthy subjects underwent a crossover study, where they consumed a berry beverage (150g blueberries, 50g blackcurrants, 50g elderberries, 50g lingonberries, 50g strawberries, and 100g tomatoes) or placebo for 5 weeks in a random order. Results showed that consuming the berry beverage, subjects performed better in working memory tests.

Nuts, specifically walnuts, also deserve a mention as a food for brain health. They contain potentially neuroprotective compounds like vitamin E, folate, melatonin, as well as omega 3 alpha-linolenic fatty acid. In a study that was published in the British Journal of Nutrition in 2012, 64 college students underwent a crossover study, where they consumed 60g of ground walnuts (in 3 slices of banana bread) or placebo for a total of 16 weeks (8 weeks per test meal). Results showed that walnuts only had an effect on deductive reasoning, but not: memory, mood or non-verbal reasoning abilities (4).

Nootropics – Proceed with Caution

When it comes to the nootropic supplements, there are concerns. For example, people have reported dependence in nootropic usage (5).  Since there isn’t much research surrounding its dose response relationship, long-term benefits and addictive properties, it’s always necessary to take precaution including informing your health professionals prior to usage.

Final Thought

Remember no single food or ingredient will instantaneously give you enlightened clarity, higher IQ, better performance or mood. A lifestyle filled with healthy habits including a balanced dietary pattern, exercise and restful sleep is the best approach for long-term consistent, mind body health.

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  1. Fang Y, Qiu Z, Hu W, Yang Jm Yi X, Huang L, Zhang S. Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis. Experimental and Therapeutic Medicine. 2014; 7: 429-434.
  2. Zhang J, Wei R, Chen Z, Luo B. Piracetam for aphasia in post-stroke patients: A systematic review and meta-analysis of randomized controlled trials. CNS Drugs. 2016; 30: 575-587
  3. Pribis P, Bailey R, Russel A, Kilby M, Hernandez M, Craig W, Grajales T, Shavlik D, Sabate J. Effects of walnut consumption on cognitive performance in young adults. British Journal of Nutrition. 2012; 107: 1393-1401
  4. DiFiore N. New MIND diet may significantly protect against alzheimer’s disease. Rush University Medical Center. 2015. Retrieved from: https://www.rush.edu/news/press-releases/new-mind-diet-may-significantly-protect-against-alzheimers-disease
  5. Mental Health Daily website. 2015. Retrieved from: https://mentalhealthdaily.com/2015/03/02/potential-dangers-of-nootropics-what-to-consider-before-using-smart-drugs/